Gut Microbiome

https://www.nature.com/articles/s41598-017-13601-y

Summary

AD's etiopathogenesis is not fully unerstood. Alterations in gut microbiome contribute to amyloid deposition. Gut microbiome of AD participants has decreased microbial diversity and compositionally distinct from control age and sex matched individuals. Some difference: decreased bifidobacterium, increased bacteroidetes, decreased firmicutes. Correlations between levels of abundant genera and CSF biomarkers of AD.

Results

APOE$\epsilon$4 genotype more prevelant in AD group.

Sequencing V4 region of 16S rRNA generated 4.8 million reads. 972 OTUs - 95 genera, 46 families, 24 order, 17 classes, 9 phyla.

AD is associated with changes in gut microbiome.

Decrease in alpha diversity in AD group compared to control group. Compositional difference also present.

Several taxa were less abundant in AD.

Potential functional changes in gut microbiome of AD participants. (phosphorylation, metabolism etc).

Abundant Genera are correlated with CSF Biomarkers of AD Pathology. Same trend between bacterial relative abundance and CSF biomarkers of AD Pathology. (More abundant in AD -> increase abundance means increase AD Pathlogy, same for less abundance in AD).

Gut microbiome has decrease richness and diversity and distinct composition to control.